Natural products are an important source of new compounds leading to drugs in all major disease areas. They represent a pool of structures that have been the source of most of the active ingredients of medicines. This article aims to provide an overview of the chemical constituents present in various parts of Cocculus hirsutus (L.) Diels belongs to family: Menispermaceae and their ethnobotanical and pharmacological actions. The phytochemical studies show the presence of bis-benzyl isoquinoline alkaloids; viz. shaheenine, cohirsinine, hirsutine, jamtinine, jamitine- N-oxide, cohirsine, dehydrocohirsine, Cohirsitine, Syringasesinol, protoquericitol, Isotriboline, Triboline and haiderine. Chemical investigation of the roots and stems of Cocculus hirsutus (L.) Diels has yielded a new phenolic alkaloid Corsutine. From the aqueous extract of dried aerial parts of Cocculus hirsutus, b-sitosterol, and 28-acetyl betulin were isolated. Almost all parts of the plant are helpful to treat different kinds of pharmacological activity such as Larvicidal, Anti-ulcer, Hepatoprotective, Antihyperglycemic, Antioxidant, Antimicrobial, Antipyretic, Anthelmintic, Anti-arthritic, Anti-fertility, Anti-tumour, Diuretic, laxative Anti-convulsant, Anti-inflammatory, analgesic activity.
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